■ Education

2010. 03 ~ 2014. 08 POSTECH, Department of Chemistry, B. S.

2014. 09 ~ 2019. 08 POSTECH, Department of Chemistry, Ph.D.

■ Experiences

2019. 09 ~ 2020. 10 POSTECH, Postdoctoral fellow

2020. 12 ~ 2022. 07 The Scripps Research Institute, Postdoctoral fellow

■ Research Field

Disease-related RNA degradation with ribonuclease

Modulation of disease-related non-coding RNAs and mRNAs

Protein-protein interaction

■ Publication

1.    Lee, Y. ^†; Liu X. ^†; Tong, Y. ^†; Child-Disney, J. ^†; Suresh, B.M.; Benhanou, R. I.; Sievers, S.; Grefe, M.; Crynen, G.; Meter, M. V.; Costales, M. G.; Abegg, D.; Haniff, H. S.; Wegner, T.; Paulisch, T. O.; Adibekian, A.; Lekah, E.; Glorius, F.; Waldmann, H.; Disney, M. D; “Biologically inactive RNA binding small molecules are rendered bioactive when converted into degraders” Nature, under revision ^†Contributed equally

2.    Lee, Y.; Heo, J.; Jeong, H.; Hong, K. T.; Kwon, D. H.; Shin, M. H.; Oh, M.; Sable, G. A.; Ahn, G.; Lee, J. S.; Lim, H. S. “Targeted Degradation of Transcription Co-activator SRC-1 through the N-Degron Pathway.” Angew. Chem. Int. Ed. 2020,59, 17548-17555.

3.    Lee, Y.; Im, H.; Oh, M.; Lee, J. H.; Das, S.; Ham, S.; Lim, H. S. “Bridged α-helix mimetic small molecules.” Chem. Commun. , 55, 13311-13314.

4.    Lee, Y.; Chung, B.; Ko, D. S.; Lim, H. S.“A solid-phase method for synthesis of dimeric and trimeric ligands: Identification of potent bivalent ligands of 14-3-3σ." Bioorg. Chem. , 91, 103141.

5.    Lee, Y.; Yoon, H.; Hwang, S. M.; Shin, M. K.; Lee, J. H.; Oh, M.; Im, S. H.; Song, J.; Lim, H. S. “Targeted Inhibition of the NCOA1/STAT6 Protein-Protein Interaction.” J. Am. Chem. Soc. 2017, 139, 16056-16059.

6.    Lee, Y.; Lim, H. S.  “Skp2 inhibitors: Novel anticancer strategies.” Curr. Med. Chem. , 23, 2363-2379.

7.    Kim, H.-S.; Lee, Y.; Shin, M. H.; Lim, H. S. "Cell-Penetrating, Amphipathic Cyclic Peptoids as Molecular Transporters for Cargo Delivery" Chem. Commun. , 57, 6800-6803.

8.    Castaneda, M.; Chen, L.; Pradhan, L.; Li, S.; Zein, R.; Lee, Y.; Lim, H. S.; Nam, H.J.; Lee, J. "A Forkhead Box Protein?C2 Inhibitor: Targeting Epithelial-Mesenchymal Transition and Cancer Metastasis. Chembiochem, 2018, 19, 1359-1364.

■ Patent

1.    H. S. Lim, Y. Lee, “Novel staple peptides for inhibiting NCOA1/STAT6 protein-protein interaction and uses thereof”, Korea Patent 10-2017-0139637 (2017) / 10-2043992 (2019)

2.    H. S. Lim, Y. Lee, “Novel PROTAC chimeric compound, and pharmaceutical composition for preventing, improving or treating diseases through target protein degradation”, Korea Patent, 10-2020-0081373 (2020)